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Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip

https://doi.org/10.1016/j.tibtech.2020.08.005

Wagner, Karl T.; Nash, Trevor R.; Liu, Bohao; Vunjak-Novakovic, Gordana; Radisic, Milica (September 2020, Trends in Biotechnology)
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Characterizing pump line phase offset of a single-soliton Kerr comb by dual comb interferometry

https://doi.org/10.1364/OL.44.001460

Kong, Ziyun; Bao, Chengying; Sandoval, Oscar E.; Liu, Bohao; Wang, Cong; Jaramillo-Villegas, Jose A.; Qi, Minghao; Weiner, Andrew M. (March 2019, Optics Letters)
Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

https://doi.org/10.1038/s41551-018-0229-7

Liu, Bohao; Lee, Benjamin W.; Nakanishi, Koki; Villasante, Aranzazu; Williamson, Rebecca; Metz, Jordan; Kim, Jinho; Kanai, Mariko; Bi, Lynn; Brown, Kristy; et al (May 2018, Nature Biomedical Engineering)

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Cell type–specific microRNA therapies for myocardial infarction

https://doi.org/10.1126/scitranslmed.abd0914

Liu, Bohao; Wang, Bryan; Zhang, Xiaokan; Lock, Roberta; Nash, Trevor; Vunjak-Novakovic, Gordana (February 2021, Science Translational Medicine)

Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.
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